Lesión pulmonar autoinducida por el paciente (P-SILI).
CRITICAL CARE & EMERGENGY MEDICINE VOL. 3
Patient self-induced lung injury (P-SILI)
- 7 diciembre, 2023
- Revisión narrativa, Volumen 3.
Gabriela Castillo Gutiérrez MD
Ernesto Deloya Tomas MD 1
, María G. Olvera Ramos MD 1
, Jorge López Fermín MD 1
, José Antonio Meade-Aguilar MD 1 *
, Jorge D. Carrión Moya MD 2 *
, Manuel A. Guerrero-Gutiérrez MD 1, 3
, Éder I. Zamarrón-López MD 4
, Orlando R. Pérez Nieto MD 1 *
.
1 Unidad de Cuidados Intensivos, Hospital General San Juan del Rio, Querétaro, México.
2 Universidad Autónoma de San Luis Potosí, San Luis Potosí, México.
3 Unidad de Cuidados Intensivos, Instituto Nacional de Cancerología, Ciudad de México, México.
4Hospital Regional IMSS No. 6, Ciudad Madero, Tamaulipas, México. Unidad de Cuidados Intensivos.
* Miembros de grupo de investigación para la ventilación mecánica AVENTHO.
Abstract
Introduction: Patient self-induced lung injury (P-SILI) is a controversial and emerging concept that refers to the fact that excessive inspi
ratory efforts by spontaneously breathing patients, whether assisted or not, can exacerbate a previously established lung injury. It is a potential complication in patients with acute respiratory distress syndrome (ARDS) who generate spontaneous ventilation during non-invasive ventilation (NIV) or invasive mechanical ventilation (IMV) that can increase the initial lung injury. Studies are required to standardize the monitoring of excessive inspiratory efforts, their implication in prognosis, and appropriate therapy.
Resumen
Introducción: La lesión pulmonar autoinducida por el paciente (P-SILI) es un concepto controvertido y emergente que hace referencia al daño pulmonar producido por los esfuerzos inspiratorios excesivos de los pacientes que respiran espontáneamente, ya sea de forma asistida o no y que puede ensombrecer el pronóstico de forma significativa.
Se requieren estudios para estandarizar el monitoreo de los esfuerzos inspiratorios excesivos, su implicación en el pronóstico y la terapéutica apropiada.
Keywords
Patient self-induced lung injury, P-SILI, acute respiratory distress syndrome, mechanical ventilation, non-invasive mechanical ventilation, and transpulmonary pressure
Biografias de autores
Gabriela Castillo Gutiérrez MD ![]()
Unidad de Cuidados Intensivos, Hospital General San Juan del Rio, Querétaro, México.
Ernesto Deloya Tomas MD ![]()
Unidad de Cuidados Intensivos, Hospital General San Juan del Rio, Querétaro, México.
María G. Olvera Ramos MD ![]()
Unidad de Cuidados Intensivos, Hospital General San Juan del Rio, Querétaro, México.
Jorge López Fermín MD ![]()
Unidad de Cuidados Intensivos, Hospital General San Juan del Rio, Querétaro, México.
José Antonio Meade-Aguilar MD ![]()
Unidad de Cuidados Intensivos, Hospital General San Juan del Rio, Querétaro, México.
Miembros de grupo de investigación para la ventilación mecánica AVENTHO.
Jorge D. Carrión Moya MD ![]()
Miembros de grupo de investigación para la ventilación mecánica AVENTHO.
Universidad Autónoma de San Luis Potosí, San Luis Potosí, México.
Manuel A. Guerrero-Gutiérrez MD ![]()
Unidad de Cuidados Intensivos, Instituto Nacional de Cancerología, Ciudad de México, México.
Unidad de Cuidados Intensivos, Hospital General San Juan del Rio, Querétaro, México.
Éder I. Zamarrón-López MD ![]()
Hospital Regional IMSS No. 6, Ciudad Madero, Tamaulipas, México. Unidad de Cuidados Intensivos.
Orlando R. Pérez Nieto MD ![]()
Miembros de grupo de investigación para la ventilación mecánica AVENTHO.
Unidad de Cuidados Intensivos, Hospital General San Juan del Rio, Querétaro, México.
Referencias
- Brun-Buisson C, Bonnet F, Bergeret S, et al. Recurrent highpermeability pulmonary edema associated with diabetic ketoacidosis. Crit Care Med. 1985;13(1):55-56. doi:10.1097/00003246-198501000-00015.
- Mascheroni D, Kolobow T, Fumagalli R, et al. Acute respiratory failure following pharmacologically induced hyperventilation: an experimental animal study. Intensive Care Med. 1988;15(1):8-14. doi:10.1007/bf00255628.
- Yoshida T, Uchiyama A, Matsuura N, et al. The Comparison of Spontaneous Breathing and Muscle Paralysis in Two Different Severities of Experimental Lung Injury. Crit Care Med. 2013;41(2):536-545. doi:10.1097/ccm.0b013e3182711972.
- West J, Mathieu-Costello O, Jones J et al. Stress failure of pulmonary capillaries in racehorses with exercise-induced pulmonary hemorrhage. J Appl Physiol. 1993;75(3):1097-1109. doi:10.1152/jappl.1993.75.3.1097.
- Hopkins S, Schoene R, Henderson W, et al. Intense exercise impairs the integrity of the pulmonary blood-gas barrier in elite athletes. Am J Respir Crit Care Med. 1997;155(3):1090-1094. doi:10.1164/ajrccm.155.3.9116992.
- Guenette J, Witt J, McKenzie D, et al. A. Respiratory mechanics during exercise in endurance-trained men and women. J Physiol. 2007;581(3):1309-1322. doi:10.1113/jphysiol.2006.126466.
- Morais C, Koyama Y, Yoshida T, et al. High Positive End-Expiratory Pressure Renders Spontaneous Effort Noninjurious. Am J Respir Crit Care Med. 2018 May 15;197(10):1285-1296. doi10.1164/rccm.201706-1244OC. PMID: 29323536; PMCID: PMC5955057.
- Lagneau F, D’honneur G, Plaud B, et al. A comparison of two depths of prolonged neuromuscular blockade induced by cisatracurium in mechanically ventilated critically ill patients. Intensive Care Med. 2002;28(12):1735-1741. doi:10.1007/s00134-002-1508-y.
- Sottile PD, Albers D, Moss MM, et al. Neuromuscular blockade is associated with the attenuation of biomarkers of epitelial and endothelial injury in patients with moderate-to-severe acute respiratory distress syndrome. Crit Care. 2018;22(1):63. doi:10.1186/s13054-018-1974-4.
- Steingrub JS, Lagu T, Rothberg MB, et al. Treatment with neuromuscular blocking agents and the risk of in-hospital mortality among mechanically ventilated patients with severe sepsis. Crit Care Med. 2014;42(1):90-96. doi:10.1097/CCM.0b013e31829eb7c9.
- Yoshida T, Grieco DL, Brochard L, et al. Patient self-inflicted lung injury and positive end-expiratory pressure for safe spontaneous breathing. Curr Opin Crit Care. 2020;26(1):59-65. doi:10.1097/MCC.0000000000000691.
- Bellani G, Grasselli G, Teggia-Droghi M, et al. Do spontaneous and mechanical breathing have similar effects on average transpulmonary and alveolar pressure? A clinical crossover study. Crit Care. 2016;20(1):142. doi:10.1186/s13054-016-1290-9.
- Yoshida T, Fujino Y, Amato MB, et al. Fifty Years of Research in ARDS. Spontaneous Breathing during Mechanical Ventilation. Risks, Mechanisms, and Management. Am J Respir Crit Care Med. 2017;195(8):985-992. doi:10.1164/rccm.201604-0748CP.
- Grieco DL, Menga LS, Eleuteri D, et al. Patient self-inflicted lung injury: implications for acute hypoxemic respiratory failure and ARDS patients on non-invasive support. Minerva Anestesiol. 2019;85(9):1014-1023. doi:10.23736/S0375-9393.19.13418-9.
- Haro C, Ochagavia A, López-Aguilar J et al. Patient-ventilator asynchronies during mechanical ventilation: current knowledge and research priorities. Intensive Care Med Exp. 2019; 7(1). doi:10.1186/s40635-019-0234-5.
- Brochard L, Slutsky A, Pesenti A. Mechanical Ventilation to Minimize Progression of Lung Injury in Acute Respiratory Failure. Am J Respir Crit Care Med. 2017;195(4):438-442. doi: 10.1164/rccm.201605-1081CP. PMID: 27626833.
- L’Her E, Deye N, Lellouche F, et al. Physiologic effects of noninvasive ventilation during acute lung injury. Am J Respir Crit Care Med. 2005; 172(9):1112-8. doi: 10.1164/rccm.200402-226OC.
- Spinelli E, Mauri T, Beitler JR, et al. Respiratory drive in the acute respiratory distress syndrome: pathophysiology, monitoring, and therapeutic interventions. Intensive Care Med. 2020; 46(4):606-618. doi: 10.1007/s00134-020-05942-6.
- Thille AW, Contou D, Fragnoli C, et al. Non-invasive ventilation for acute hypoxemic respiratory failure: intubation rate and risk factors. Crit Care. 2013;17. doi: 10.1186/cc13103.
- Bellani G, Laffey JG, Pham T, et al. Noninvasive Ventilation of Patients with Acute Respiratory Distress Syndrome. Insights from the LUNG SAFE Study. Am J Respir Crit Care Med. 2017;195(1):67-77. doi:10.1164/rccm.201606-1306OC.
- Tobin, M.J., Laghi, F. & Jubran, A. P-SILI is not justification for intubation of COVID-19 patients. Ann. Intensive Care 10, 105 (2020). https://doi.org/10.1186/s13613-020-00724-1.
- Gattinoni, L., Marini, J.J., Busana, M. et al. Spontaneous breathing, transpulmonary pressure and mathematical trickery. Ann. Intensive Care 10, 88 (2020). https://doi.org/10.1186/s13613-020-00708-1.
- Papazian L, Aubron C, Brochard L, et al. Formal guidelines: management of acute respiratory distress syndrome. Ann Intensive Care. 2019;9(1):69. Published 2019 Jun 13. doi:10.1186/s13613-019-0540-9.
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