Tromboprofilaxis en el paciente sometido a cirugía bariátrica: revisión de la literatura.

CRITICAL CARE & EMERGENGY MEDICINE VOL. 3

Management of Acute Myocardial Infarction with ST Segment Elevation. Narrative Review.

Natasha Mey Ruiz 1, David Barney Briseño 2, Santiago Andrés Berrón Pérez 1, Irlanda Guerrero Barajas 1, José Ricardo Solorzanó Beltrán 1, Manuel Alberto Guerrero Gutiérrez 3. 

1 Fellow en Alta Especialidad en Anestesiología Bariátrica. Tijuana, México.
2 Departamento de Cirugía Bariátrica y Metabólica en Centro Quirúrgico J.L.Prado, Tijuana, México.
3 Departamento de Anestesiología Bariátrica, Centro Médico Bariátrico. Tijuana, México.

Abstract

Thromboembolic disease is a pathological condition that encompasses deep vein thrombosis (DVT) and pulmonary embolism (PE). Obese individuals have a 2 to 3 times greater risk of developing venous thromboembolism (VTE); several pathophysiological mechanisms contribute to this correlation. The incidence of VTE in patients who have undergone bariatric surgery ranges from 0.1 to 3% and represents 20% of related mortality. The previous history of VTE, long surgical time (>3 hours) and the need for transfusion were the risk factors with the greatest impact on bariatric surgery. Thromboembolic risk stratification is essential to guide thromboprophylaxis. There are three tools specifically designed for bariatric surgery: The Cleveland Clinic calculator, BariClot and MBSC. Prophylaxis strategies include mechanical and pharmacological interventions. Various methods have been compared with the intention of identifying the most appropriate regimen for this patient population, however, evidence remains limited and results vary widely, so there is no consensus on the best treatment. This paper aims to carryout a narrative review of the most recent literature on thromboprophylaxis in patients undergoing bariatric surgery.

La enfermedad tromboembólica es una entidad patológica que abarca la trombosis venosa profunda (TVP) y la embolia pulmonar (EP). Los individuos con obesidad tienen un riesgo de desarrollar tromboembolismo venoso (TEV) de 2 a 3 veces mayor; diversos mecanismos fisiopatológicos contribuyen a esta correlación. La incidencia de TEV en pacientes que se han sometido a cirugía bariátrica oscila entre 0.1 – 3% y representa el 20% de la mortalidad relacionada. La historia previa de TEV, tiempo quirúrgico prolongado (>3 horas) y la necesidad de transfusión, fueron los factores de riesgo de mayor impacto en cirugía bariátrica. La estratificación del riesgo tromboembólico es esencial para guiar la tromboprofilaxis. Existen tres herramientas específicamente diseñadas para cirugía bariátrica: la calculadora de The Cleveland Clinic, BariClot y MBSC. Las estrategias de profilaxis incluyen intervenciones mecánicas y farmacológicas. Se han comparado diversos esquemas con la intención de identificar el régimen más adecuado para esta población de pacientes, sin embargo, la evidencia sigue siendo limitada y los resultados varían ampliamente, por lo que no existe un consenso sobre el mejor tratamiento. Este trabajo pretende realizar una revisión narrativa de la literatura más reciente sobre la tromboprofilaxis en pacientes sometidos a cirugía bariátrica. 

Venous thromboembolism; obesity; bariatric surgery; prophylaxis; low molecular weight heparin; direct oral anticoagulants; anti-Xa.

Natasha Mey Ruiz
Fellow en Alta Especialidad en Anestesiología Bariátrica. Tijuana, México.

David Barney Briseño
Departamento de Cirugía Bariátrica y Metabólica en Centro Quirúrgico J.L.Prado, Tijuana, México.

Santiago Andrés Berrón Pérez
Fellow en Alta Especialidad en Anestesiología Bariátrica. Tijuana, México.

Irlanda Guerrero Barajas
Fellow en Alta Especialidad en Anestesiología Bariátrica. Tijuana, México.

José Ricardo Solorzanó Beltrán
Fellow en Alta Especialidad en Anestesiología Bariátrica. Tijuana, México.

Manuel Alberto Guerrero Gutiérrez. 
Departamento de Anestesiología Bariátrica, Centro Médico Bariátrico. Tijuana, México.

  1. Chooi YC, Ding C, Magkos F, Magkos F, Magkos F. The epidemiology of obesity. Metabolism-Clinical and Experimental 2019;92:6–10. https://doi.org/10.1016/J.METABOL.2018.09.005.
  2. Obesity and overweight. World Health Organization 2024. https://www.who.int/news-room/fact-sheets/detail/obesityand-overweight (accessed October 6, 2024).
  3. Lindström S, Germain M, Germain M, Crous-Bou M, Smith EN, Morange P-E, et al. Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study. Human Genetics 2017;136:897–902. https://doi.org/10.1007/S00439-017-1811-X.
  4. Ceccato D, Di Vincenzo A, Pagano C, Pesavento R, Prandoni P, Vettor R. Weight-adjusted versus fixed dose heparin thromboprophylaxis in hospitalized obese patients: A systematic review and meta-analysis. European Journal of Internal Medicine 2021;88:73–80. https://doi.org/10.1016/J.EJIM.2021.03.030.
  5. Hamadi R, Marlow CF, Nassereddine S, Taher AT, Finianos A. Bariatric venous thromboembolism prophylaxis: an update on the literature. Expert Review of Hematology 2019;12:763–71. https://doi.org/10.1080/17474086.2019.1634542.
  6. Overby DW, Kohn GP, Cahan MA, Galanko JA, Colton KJ, Moll S, et al. Prevalence of thrombophilias in patients presenting for bariatric surgery. Obesity Surgery 2009;19:1278–85. https://doi.org/10.1007/S11695-009-9906-7.
  7. Miranda S, Le Cam-Duchez V, Benichou J, Donnadieu N, Barbay V, Le Besnerais M, et al. Adjusted value of thromboprophylaxis in hospitalized obese patients: A comparative study of two regimens of enoxaparin: The ITOHENOX study. Thrombosis Research 2017;155:1–5. https://doi.org/10.1016/J.THROMRES.2017.04.011.
  8. Vaughn SC, Talutis SD, Cassidy MR, Sachs TE, Drake FT, Rosenkranz P, et al. Two novel risk factors for postoperative venous thromboembolism: A reconsideration of standard risk assessment and prophylaxis. American Journal of Surgery 2020;220:1338–43. https://doi.org/10.1016/J.AMJSURG.2020.06.068.
  9. Kröll D, Nett P, Rommers N, Borbély YM, Deichsel F, Nocito A, et al. Efficacy and Safety of Rivaroxaban for Postoperative Thromboprophylaxis in Patients After Bariatric Surgery. JAMA Network Open 2023;6:e2315241. https://doi.org/10.1001/jamanetworkopen.2023.15241.
  10. Gambhir S, Inaba CS, Alizadeh RF, Nahmias J, Hinojosa MW, Smith BR, et al. Venous thromboembolism risk for the contemporary bariatric surgeon. Surgical Endoscopy and Other Interventional Techniques 2020;34:3521–6. https://doi.org/10.1007/S00464-019-07134-W.
  11. O’Connor K, Garcia Whitlock AE, Tewksbury C, Williams NN, Dumon K. Risk factors for postdischarge venous thromboembolism among bariatric surgery patients and the evolving approach to extended thromboprophylaxis with enoxaparin. Surgery for Obesity and Related Diseases 2021;17:1218–25. https://doi.org/10.1016/J.SOARD.2021.02.023.
  12. Imbus JR, Jung AD, Davis S Jr, Oyefule OO, Patel AD, Serrot FJ, Stetler JL, Majumdar MC, Papandria D, Diller ML, Srinivasan JK, Lin E, Hechenbleikner EM. Extended postoperative venous thromboembolism prophylaxis after bariatric surgery: a comparison of existing risk-stratification tools and 5-year MBSAQIP analysis. Surg Obes Relat Dis. 2023 Aug;19(8):808-816. doi: 10.1016/j.soard.2023.04.329.
  13. El Ansari W, El-Menyar A, El-Ansari K, Al-Ansari A, Lock M. Cumulative Incidence of Venous Thromboembolic Events In-Hospital, and at 1, 3, 6, and 12 Months After Metabolic and Bariatric Surgery: Systematic Review of 87 Studies and Meta-analysis of 2,731,797 Patients. Obes Surg. 2024 Jun;34(6):2154-2176. doi: 10.1007/s11695-024-07184-7.
  1. Carvalho L, Almeida RF, Nora M, Guimarães M. Thromboembolic Complications After Bariatric Surgery: Is the High Risk Real? Cureus. 2023 Jan 6;15(1):e33444. doi: 10.7759/cureus.33444.
  2. Harrington LB, Benz L, Haneuse S, Johnson E, Coleman KJ, Courcoulas AP, Li RA, Theis MK, Cooper J, Chin PL, Grinberg GG, Daigle CR, Chang JH, Um SS, Yenumula PR, Getty JZ, Arterburn DE. Bariatric Surgery and the Long-Term Risk of Venous Thromboembolism: A Population-Based Cohort Study. Obes Surg. 2024 Jun;34(6):2017-2025. doi: 10.1007/s11695-024-07236-y.
  3. Mey-Ruiz N, Veyna-Rocha AI, Berrón-Pérez A. Consideraciones farmacológicas para el paciente con obesidad. En: GuerreroGutiérrez MA, coordinador. Anestesiología Bariátrica y para el paciente con obesidad. 1ra. Ed. México: Ediciones Prado; 2024. Pp(131-152). Doi:http://doi.org/10.58281/ep100724.
  1. Bartlett MA, Mauck KF, Stephenson CR, Ganesh R, Daniels PR. Perioperative Venous Thromboembolism Prophylaxis. Mayo Clin Proc. 2020 Dec;95(12):2775-2798. doi: 10.1016/j.mayocp.2020.06.015.
  2. Finks JF, English WJ, Carlin AM, Krause KR, Share DA, Banerjee M, Birkmeyer JD, Birkmeyer NJ; Michigan Bariatric Surgery Collaborative; Center for Healthcare Outcomes and Policy. Predicting risk for venous thromboembolism with bariatric surgery: results from the Michigan Bariatric Surgery Collaborative. Ann Surg. 2012 Jun;255(6):1100-4. doi: 10.1097/SLA.0b013e31825659d4.
  1. Aminian A, Andalib A, Khorgami Z, Cetin D, Burguera B, Bartholomew J, Brethauer SA, Schauer PR. Who Should Get Extended Thromboprophylaxis After Bariatric Surgery?: A Risk Assessment Tool to Guide Indications for Post-discharge Pharmacoprophylaxis. Ann Surg. 2017 Jan;265(1):143-150. doi: 10.1097/SLA.0000000000001686. PMID: 28009739.
  2. Dang JT, Switzer N, Delisle M, Laffin M, Gill R, Birch DW, Karmali S. Predicting venous thromboembolism following laparoscopic bariatric surgery: development of the BariClot tool using the MBSAQIP database. Surg Endosc. 2019 Mar;33(3):821-831. doi: 10.1007/s00464-018-6348-0.
  3. Mechanick JI, Apovian C, Brethauer S, Timothy Garvey W, Joffe AM, Kim J, Kushner RF, Lindquist R, Pessah-Pollack R, Seger J, Urman RD, Adams S, Cleek JB, Correa R, Figaro MK, Flanders K, Grams J, Hurley DL, Kothari S, Seger MV, Still CD. Clinical Practice Guidelines for the Perioperative Nutrition, Metabolic, and Nonsurgical Support of Patients Undergoing Bariatric Procedures – 2019 Update: Cosponsored by American Association of Clinical Endocrinologists/American College of Endocrinology, The Obesity Society, American Society for Metabolic and Bariatric Surgery, Obesity Medicine Association, and American Society of Anesthesiologists. Obesity (Silver Spring). 2020 Apr;28(4):O1-O58. doi: 10.1002/oby.22719.
  4. Anderson DR, Morgano GP, Bennett C, Dentali F, Francis CW, Garcia DA, Kahn SR, Rahman M, Rajasekhar A, Rogers FB, Smythe MA, Tikkinen KAO, Yates AJ, Baldeh T, Balduzzi S, Brożek JL, Ikobaltzeta IE, Johal H, Neumann I, Wiercioch W, Yepes-Nuñez JJ, Schünemann HJ, Dahm P. American Society of Hematology 2019 guidelines for management of venous thromboembolism: prevention of venous thromboembolism in surgical hospitalized patients. Blood Adv. 2019 Dec 10;3(23):3898-3944. doi: 10.1182/bloodadvances.2019000975.
  1. Amaral FC, Baptista-Silva JC, Nakano LC, Flumignan RL. Pharmacological interventions for preventing venous thromboembolism in people undergoing bariatric surgery. Cochrane Database Syst Rev. 2022 Nov 22;11(11):CD013683. doi: 10.1002/14651858.CD013683.pub2.
  1. Kubitza D, Berkowitz SD, Misselwitz F. Evidence-Based Development and Rationale for Once-Daily Rivaroxaban Dosing Regimens Across Multiple Indications. Clin Appl Thromb Hemost. 2016 Jul;22(5):412-22. doi: 10.1177/1076029616631427.
  2. Kushnir M, Gali R, Alexander M, Billett HH. Direct oral Xa inhibitors for the treatment of venous thromboembolism after bariatric surgery. Blood Adv. 2023 Jan 24;7(2):224-226. doi: 10.1182/bloodadvances.2021006696.
  3. Martin KA, Beyer-Westendorf J, Davidson BL, Huisman MV, Sandset PM, Moll S. Use of direct oral anticoagulants in patients with obesity for treatment and prevention of venous thromboembolism: Updated communication from the ISTH SSC Subcommittee on Control of Anticoagulation. J Thromb Haemost. 2021 Aug;19(8):1874-1882. doi: 10.1111/jth.15358
  4. Kröll D, Nett PC, Borbély YM, Schädelin S, Bertaggia Calderara D, Alberio L, Stirnimann G. The effect of bariatric surgery on the direct oral anticoagulant rivaroxaban: the extension study. Surg Obes Relat Dis. 2018 Dec;14(12):1890-1896. doi: 10.1016/j.soard.2018.08.025.
  1. Gaborit B, Moulin PA, Bege T, Boullu S, Vincentelli C, Emungania O, Morange PE, Berdah S, Salem JE, Dutour A, Frere C. Lean body weight is the best scale for venous thromboprophylaxis algorithm in severely obese patients undergoing bariatric surgery. Pharmacol Res. 2018 May;131:211-217. doi: 10.1016/j.phrs.2018.02.012.
  2. Gibson CM, Hall C, Davis S, Schillig JM. Comparison of two escalated enoxaparin dosing regimens for venous thromboembolism prophylaxis in obese hospitalized patients. J Thromb Thrombolysis. 2021 Aug;52(2):577-583. doi: 10.1007/s11239-020-02360-9.
  3. Karas LA, Nor Hanipah Z, Cetin D, Schauer PR, Brethauer SA, Daigle CR, Aminian A. Assessment of empiric body mass indexbased thromboprophylactic dosing of enoxaparin after bariatric surgery: evidence for dosage adjustment using anti-factor Xa in high-risk patients. Surg Obes Relat Dis. 2021 Jan;17(1):153-160. doi: 10.1016/j.soard.2020.08.016
  4. Arcelus JI, Gouin-Thibault I, Samama CM. European guidelines on peri-operative venous thromboembolism prophylaxis: first update.: Chapter 10: Surgery in the obese patient. Eur J Anaesthesiol. 2024 Aug 1;41(8):607-611. doi: 10.1097/EJA.0000000000002000.
  5. Godier A, Lasne D, Pernod G, Blais N, Bonhomme F, Bounes F, Bourguignon A, Cohen A, de Maistre E, Fontana P, Galanaud JP, Huet DG, Godon A, Gouin-Thibault I, Jebara S, Laporte S, Lecompte T, Longrois D, H Levy J, Le Gal G, Gruel Y, Mansour A, Martin AC, Mazighi M, Morange PE, Motte S, Mullier F, Nguyen P, Rosencher N, Roullet S, Roy PM, Schved JF, Sevestre MA, Sié P, Susen S, Tacquard C, Vincentelli A, Zufferey P, Mismetti P, Albaladejo P. Prevention of perioperative venous thromboembolism: 2024 guidelines from the French Working Group on Perioperative Haemostasis (GIHP) developed in collaboration with the French Society of Anaesthesia and Intensive Care Medicine (SFAR), the French Society of Thrombosis and Haemostasis (SFTH) and the French Society of Vascular Medicine (SFMV) and endorsed by the French Society of Digestive Surgery (SFCD), the French Society of Pharmacology and Therapeutics (SFPT) and INNOVTE (Investigation Network On Venous ThromboEmbolism) network. Anaesth Crit Care Pain Med. 2024 Oct 22:101446. doi: 10.1016/j.accpm.2024.101446.

[1] Natasha Mey Ruiz, David Barney Briseño, Santiago Andrés Berrón Pérez, Irlanda Guerrero Barajas, José Ricardo Solorzanó Beltrán, and Manuel Alberto Guerrero Gutiérrez. 2024. Tromboprofilaxis en el paciente sometido a cirugía bariátrica: revisión de la literatura. CRITICAL CARE & EMERGENGY MEDICINE. Vol. 3, pp. 1–10. DOI: www.doi.org/10.58281/ccem24120906.

Licencia

© 2025 Critical Care & Emergency Medicine by Ediciones Prado. This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0) .

Licencia Creative Commons CC BY 4.0

The copyrights of the articles published in Critical Care & Emergency Medicine belong to Ediciones Prado. The contents of the articles that appear in the Journal are exclusively the responsibility of the authors and do not necessarily reflect the opinions of the Editorial Committee of the Journal. It is allowed to reproduce the material published in Critical Care & Emergency Medicine without prior authorization for non-commercial use.

ISSN

2992-6785

eISSN: 2992-6785
DOI: 10.3989/ccem

Indexación

Patrocinadores

Scroll al inicio